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Melanie Jambeau, PhD Student

I am doing a collaborative PhD in Lagier-Tourenne lab and Polymenidou lab (at the University of Zurich, Switzerland). Both groups are focused on understanding the causes leading to this devastating disease in order to find a cure. During my master thesis with Clotilde Lagier-Tourenne, I was working on understanding whether FUS gains or loses its regulating functions linked to RNA processing (splicing and expression level).

I am now trying to understand the mechanisms controlling the expression level of long genes. Initially, Magdalini Polymenidou and Clotilde Lagier-Tourenne showed that FUS and TDP-43, two proteins mutated in ALS, regulate long intron-containing genes expression. Very recent studies highlight the crucial role of long genes in brain function and incriminate exceptionally long genes in another neurological disorder. I will investigate how FUS and TDP-43 regulate this particular set of genes and will try to restore their expression to see if it can improve neuronal health.

 

M.S., in RNA Biology at the University of Lorraine, Nancy, France 2014

Graduated as a PT at the School of Physical Therapy, Nancy, France (ILFMK) 2010